Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress

Figure 6 Inhibitory effect of doxycycline on matrix metalloproteinase activity in rat gastric tissue extract in vitro. A: Gelatin and casein zymography of gastric tissue extract following treatment with doxycycline or 1, 10-phenanthroline at two different concentrations; B: Histographic representation of pro-matrix metalloproteinase (MMP)-3, proMMP-2 and proMMP-9 activities as measured by Lab Image software using the above zymograms and two other representative zymograms from independent experiments. Data expressed as mean ± SE. ^bP < 0.01, ^dP < 0.001 vs control phenanthroline was labeled as Phen in the figure.