Doxycycline blocks gastric ulcer by regulating matrix metalloproteinase-2 activity and oxidative stress

Figure 1 Protective effect of doxycycline on gastric injury. Gastric ulcers were induced in rats by oral administration of 48 mg/kg indomethacin or 70% ethanol (low and high) doses. Doxycycline (50 mg/kg) was administered orally prior to ulcerogen treatment to assess the protective effect. Control rats received sterile water only. After 3 h, rats were sacrificed and ulcer indices were scored. Mean ulcer index for indomethacin-induced (A) and ethanol-induced (B) ulceration in each group of rats was plotted. Dox: Doxycycline; Con: Control; Indo: Indomethacin; L.EtOH: Low dose ethanol; H.EtOH: High dose ethanol. Data expressed as mean ± SE. ^aP < 0.05, ^bP < 0.001 vs control; ^cP < 0.001 vs indomethacin; ^dP < 0.001 vs high dose ethanol; ^eP < 0.01 vs low dose ethanol.