Survival trends in gastric cancer patients of Northeast China

Table 2 HR for death in population (n =1604) - univariable and multivariable analyses

	Univariable analyses		Multivariable analyses
	HR (95% CI)	P	HR (95% CI)	P
Age (yr)		0		0.005
≤ 55	1 (Ref)		1 (Ref)
> 55	1.383 (1.222-1.565)	0	1.240 (1.036-1.484)	0.019
Sex		0.734		0.582
Male	1 (Ref)		1  (Ref)
Female	0.977 (0.855-1.117)	0.734	1.030 (0.854-1.241)	0.760
Tumor size		0		0.024
≤ 5 cm	1 (Ref)		1 (Ref)
5-7 cm	1.782 (1.534-2.071)	0	1.250 (1.006-1.553)	0.044
> 7 cm	2.587 (2.244-2.982)	0	1.211 (0.956-1.533)	0.113
Tumor site		0		0.071
Whole stomach	1 (Ref)		1 (Ref)
Upper stomach	0.625 (0.489-0.798)	0	1.247 (0.825-1.886)	0.295
Middle stomach	0.358 (0.273-0.471)	0	0.844 (0.541-1.315)	0.453
Lower stomach	0.401 (0.327-0.490)	0	0.846 (0.574-1.247)	0.399
> 2/3 stomach	0.588 (0.475-0.727)	0	0.845 (0.590-1.210)	0.358
Gross appearance		0		0.002
Borrmann types I	1 (Ref)		1 (Ref)
Borrmann types II	0.541 (0.338-0.867)	0.011	0.405 (0.179-0.915)	0.030
Borrmann types III	0.807 (0.510-1.278)	0.361	0.626 (0.284-1.381)	0.246
Borrmann types IV	1.357 (0.841-2.191)	0.211	1.328 (0.317-1.672)	0.454
Tumor stage		0		0.408
T1	1 (Ref)		1 (Ref)
T2	3.336 (2.542-4.377)	0	1.458 (0.797-2.667)	0.221
T3	4.275 (3.218-5.678)	0	1.780 (0.510-2.287)	0.841
T4	7.873 (5.689-10.894)	0	1.991 (0.459-2.590)	0.844
Lymph-node stage		0		0.874
N0	1 (Ref)		1 (Ref)
N1	2.980 (2.411-3.682)	0	1.176 (0.913-2.073)	0.127
N2	3.430 (2.754-4.271)	0	1.443 (0.595-1.826)	0.883
N3	5.174 (3.934-6.804)	0	1.756 (0.324-2.766)	0.518
TNM stage		0		0.019
IA	1 (Ref)		1 (Ref)
IB	1.920 (1.381-2.671)	0	0.642 (0.288-1.431)	0.279
II	2.645 (1.938-3.608)	0	0.779 (0.293-2.068)	0.616
IIIA	4.306 (3.171-5.847)	0	1.303 (0.429-3.961)	0.641
IIIB	4.847 (3.510-6.693)	0	1.459 (0.409-5.204)	0.561
IV	8.982 (6.613-12.199)	0	3.286 (0.779-13.857)	0.105
Surgery		0		0
Absolutely curative	1 (Ref)		1 (Ref)
Relatively curative	1.907 (1.631-2.230)	0	1.372 (1.114-1.690)	0.003
Palliative	4.368 (3.782-5.044)	0	3.361 (1.752-6.448)	0
Lymph node dissection		0		0.867
D1	1 (Ref)		1 (Ref)
D2	0.931 (0.750-1.155)	0.515	1.169 (0.821-1.664)	0.387
D3	0.807 (0.616-1.058)	0.121	1.146 (0.738-1.780)	0.543
Palliative resection	3.236 (2.573-4.070)	0	1.359 (0.457-1.612)	0.636
Joint organ removal		0		0.007
None	1 (Ref)		1 (Ref)
Pancreas or spleen	1.997 (1.640-2.433)	0	1.086 (0.709-1.372)	0.933
Liver or gall	1.514 (1.029-2.227)	0.035	1.108 (0.649-1.891)	0.707
Transverse colon	2.093 (1.699-2.579)	0	1.466 (1.107-1.942)	0.008
Other	2.453 (1.797-3.350)	0	1.008 (0.586-1.731)	0.978
Gastrectomy		0		0.512
Total	1 (Ref)		1 (Ref)
Subtotal	0.573 (0.494-0.664)	0	0.912 (0.693-1.200)	0.511
Hepatic metastasis		0		0.796
No	1 (Ref)		1 (Ref)
Yes	4.002 (2.991-5.354)	0	1.285 (0.403-1.529)	0.476
Peritoneum metastasis		0		0.947
No	1 (Ref)		1 (Ref)
Yes	2.835 (2.359-3.406)	0	1.127 (0.382-1.381)	0.329
Complication		0.41		0.157
None	1 (Ref)		1 (Ref)
Intestinal obstruction	0.796 (0.522-1.216)	0.292	1.311 (0.670-2.565)	0.428
Anastomotic leakage	1.474 (0.946-2.294)	0.086	1.893 (0.904-3.965)	0.091
Pneumonia	1.069 (0.400-2.856)	0.894	1.207 (0.323-4.525)	0.929
Abdominal abscess	1.212 (0.795-1.850)	0.372	1.295 (0.700-2.397)	0.410
Anaemia	0.487 (0.157-1.514)	0.214	0.479 (0.116-1.980)	0.309
Other	0.702 (0.421-1.172)	0.176	0.488 (0.240-0.992)	0.047
Adjunctive therapy		0.022		0.364
No	1 (Ref)		1 (Ref)
Yes	0.744 (0.577-0.959)	0.022	0.850 (0.643-1.124)	0.254
Diagnosis period		0.395		0.385
1980s	1 (Ref)		1 (Ref)
1990s	1.072 (0.937-1.226)	0.311	1.025 (0.807-1.301)	0.840
2000s	0.884 (0.735-1.063)	0.191	0.914 (0.674-1.241)	0.565