Intestinal inflammation and colorectal cancer: A double-edged sword?

Figure 1 Different T helper-mediated immune responses might be associated with distinct effects on dysplastic cell survival. While Th2 and Th17 immune responses might promote dysplastic cell proliferation and tumor growth, Th1 cells could induce cell death thus preventing tumor progression. Th: T helper; NK: Natural killer; NKT: Natural killer T cells; IL: Interleukin; TGF-β: Transforming growth factor-β; DC: Dendritic cells; MHC: Major histocompatibility complex; Fas: Tumor necrosis factor receptor superfamily, member 6; NKG2D: Killer cell lectin-like receptor subfamily K, member 1; TNF-α: Tumor necrosis factor-α; sIL6R-α: Soluble IL-6 receptor-α.