Down-regulation of STAT3 expression by vector-based small interfering RNA inhibits pancreatic cancer growth

Figure 4 Effects of silence of signal transduction and activation of transcription 3 gene on tumorigenicity in vivo. In vivo assay was done as described in materials and methods. Six weeks after injection, tumors were harvested and analyzed. Tumors from pRNAT-STAT3-siRNA-II–infected SW1990 cells were significantly smaller than those of control mice. Columns: mean (n = 6); Bars: SD. ^aP < 0.05 vs control. SW1990-Con: SW1990 pRNAT-Con transfectants; SW1990-RNAi: SW1990 STAT3-RNAi transfectants.