Antitumor activity of mutant bacterial cytosine deaminase gene for colon cancer

doi:10.3748/wjg.v17.i24.2958

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Jun 28, 2011 (publication date) through Aug 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2011; 17(24): 2958-2964
Published online Jun 28, 2011. doi: 10.3748/wjg.v17.i24.2958

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Figure 4 Growth of LoVo, LoVo/null, LoVo/bCDwt, and LoVo/bCD-D314A xenografts treated with PBS or 5-fluorocytosine. Treatment was started on 14 d after tumor cell inoculation. PBS or 5-fluorocytosine (5-FC) (500 mg/kg) was injected intraperitoneal once a day for 14 d. Data points represent the mean tumor volume of each group of animals. bCD: Bacterial cytosine deaminase; bCDwt: Wild-type bCD; bCD-D314A: bCD mutant D314A; LoVo/null: LoVo cell transfected with pLJM1-GFP; LoVo/bCDwt: LoVo cell transfected with pLJM1-bCDwt-GFP; LoVo/bCD-D314A: LoVo cell transfected with pLJM1-bCD-D314A-GFP.

Citation: Deng LY, Wang JP, Gui ZF, Shen LZ. Antitumor activity of mutant bacterial cytosine deaminase gene for colon cancer. World J Gastroenterol 2011; 17(24): 2958-2964
URL: https://www.wjgnet.com/1007-9327/full/v17/i24/2958.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i24.2958