Genomic imbalances in esophageal carcinoma cell lines involve Wnt pathway genes

Table 2 Amplification peaks as detected by the GISTIC algorithm

Cytoband	Location (kb)	Approx size (Mb)	Frequency (n/5)	Mean log2ratio1	q-value	Genes2
1p34.2	Chr1:39027237-40780163	1.75	3	1.10	0.18	MYCL1
3q11.2-q12.2	Chr3:95917505-101945216	6.02	4	1.40	0.17	MINA
5p15.2	Chr5:10051329-11800765	1.75	2	1.36	0.09	CTNND2
7p11.2-p13	Chr7:45294289-57299457	12.01	1	1.24	0.13	EGFR
8q24.21	Chr8:127445828-129661846	2.22	5	2.10	0.0007	MYC
9q31.1	Chr9:100905143-102152148	1.25	1	2.57	0.15
10q12.33-q21.3	Chr10:17811791-65388337	47.58	1	3.05	0.13
11q13.3	Chr11:68753086-69985447	1.23	4	1.81	5.76E-05	CCND1, CTTN, FGF3, FGF4, FGF19, MYEOV
11q22.1-q22.3	Chr11:100815801-103042620	2.23	2	2.35	0.03	BIRC2, BIRC3, YAP1
18p11.32	Chr18:1-1118244	1.12	2	1.04	0.13	TYMS, YES1
20p11.1-p11.22	Chr20:22140447-26145930	4.01	2	1.24	0.13	PYGB
22q11.21	Chr22:16558724-17937900	1.38	2	1.20	0.21	BID, CLDN5
22q11.21-q11.22	Chr22:18577713-20667607	2.10	2	1.20	0.13	CRKL, MAPK1
22q12.3	Chr22:31889314-32003182	0.11	2	1.15	0.13	LARGE

¹The mean log2ratio for the samples with a log2ratio > 0.9 (equivalent to 3.7 copies per diploid cell);

²The selected genes from the peak region.