Molecular biology of pancreatic cancer

Table 3 Overview of hereditary syndromes predisposing to pancreatic cancer

Syndrome	Gene	Life-time risk	Relative risk
FAMMM	CDKN2A	10%-15%	20-34
HBOC	BRCA2	5%	10
HBOC	BRCA1	Not known	2
Hereditary pancreatitis	PRSS1/TRY1	30%-50%	50
Lynch syndrome	MLH1/MSH2	Not known	Not known
Peutz–Jeghers syndrome	STK11/LKB1	36%	136
FAP	APC	Not known	4
Li–Faumeni syndrome	p53	Not known	Not known
FPC	Not known	Up to 50%	18-57

APC: Adenomatous polyposis coli; FAMMM: Familial atypical multiple mole melanoma; FAP: Familial adenomatous polyposis; FPC: Familial pancreatic cancer; HBOC: Hereditary breast and ovarian syndrome. Adapted from[72].