Molecular biology of pancreatic cancer

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Jun 28, 2011 (publication date) through Jul 5, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2011; 17(24): 2897-2908
Published online Jun 28, 2011. doi: 10.3748/wjg.v17.i24.2897

Table 2 Genes most frequently mutated in pancreatic cancer[45,46]

Gene symbols	Protein name	Mutation frequency (%)	Type	Main signaling or system
KRAS	K-ras	58	Proto-oncogene	Ras/Raf/MAPK
TP53	Tumor protein p53	37	Tumor suppressor	Apoptosis Cell cycle control
CDKN2A	Tumor protein p16 (INK4A)	29	Tumor suppressor	Cell cycle control
CTNNB1	β-catenin	24	Proto-oncogene	Wnt
SMAD4 DPC4	Smad Dpc4	22	Tumor suppressor	TNFbeta/SMAD
APC	Apc	16	Tumor suppressor	Wnt
PIK3CA	Phosphoinositide 3-kinase	5	Proto-oncogene	PTEN/PI3K/AKT

DPC: Deleted in pancreatic cancer; APC: Adenomatous polyposis coli; MAPK: Mitogen-activated protein kinase.

Citation: Zavoral M, Minarikova P, Zavada F, Salek C, Minarik M. Molecular biology of pancreatic cancer. World J Gastroenterol 2011; 17(24): 2897-2908
URL: https://www.wjgnet.com/1007-9327/full/v17/i24/2897.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i24.2897