Log-normal censored regression model detecting prognostic factors in gastric cancer: A study of 3018 cases

Table 3 Multivariate model of Cox and log normal regression with prognostic factors (full model and final model)

	Cox HR (95% CI)		Log normal HR (95% CI)
	Full model (AIC = 1508.49)	Final model (AIC = 2534.72)	Full model (AIC = 913.34)	Final model (AIC = 1693.56)
Sex
Male	0.91 (0.801-1.034)		0.886 (0.781-1.005)
Female	1.00
Age at diagnosis	1.0141 (1.009-1.02)	1.0111 (1.006-1.017)	1.0151 (1.010-1.021)	1.0151 (1.009-1.020)
Past history
Without	1.00	1.00	1.00	1.00
With	0.8401 (0.738-0.955)	0.8581 (0.755-0.975)	0.8131 (0.716-0.914)	0.8091 (0.713-0.919)
Family history
Without	1.00		1.00	1.00
With	0.957 (0.8254-1.11)		0.967 (0.833-1.234)
Cancer number
Single	1.00		1.00
Multiple	1.21 (0.861-1.701)		1.312 (1.935-1.840)
Cancer location
Lower third	1.00		1.00	1.00
Middle third	1.033 (0.885-1.205)		1.1351 (1.073-1.199)	1.1291 (1.069-1.194)
Upper third	1.4061 (1.173-1.686)		1.2881 (1.224-1.353)	1.2771 (1.211-1.338)
Total stomach	1.4661 (1.214-1.771)		1.4621 (1.365-1.558)	1.4391 (1.343-1.535)
Distant metastasis
Absent	1.00		1.00	1.00
Present	1.211 (1.013-1.447)		1.2051 (1.011-1.437)	1.1981 (1.009-1.424)
Surgical curative degree
Absolutely radical	1.00	1.00	1.00	1.00
Relatively radical	1.3891 (1.197-1.611)	1.3831 (1.194-1.601)	1.7241 (1.537-1.934)	1.6721 (1.538-1.817)
Palliative	3.8891 (2.583-5.855)	2.6871 (2.316-3.116)	2.9721 (2.770-3.174)	2.7961 (2.653-2.938)
Lymph node dissection
> D2	1.00		1.00
D2	0.908 (0.784-1.051)		0.967 (0.892-1.049)
D1	0.901 (0.712-1.14)		0.935 (0.855-1.015)
< D1	0.6071 (0.395-0.935)		0.904 (0.784-1.024)
Combined other organ resection
Without	1.00		1.00
With	1.4061 (1.227-1.61)		1.4471 (1.264-1.657)
Histologic types
Well differentiated	1.00		1.00	1.00
Middle differentiated	1.056 (0.878-1.271)		1.1101 (1.042-1.183)	1.1201 (1.051-1.193)
Poor differentiated	1.1791 (1.035-1.343)		1.2321 (1.160-1.304)	1.2541 (1.182-1.327)
Borrmann classification
I	1.00	1.00	1.00	1.00
II	1.142 (0.957-1.319)	1.201 (1.068-1.433)	1.018 (0.943-1.106)	1.015 (0.941-1.102)
III	1.3151 (1.113-1.672)	1.3941 (1.205-1.741)	1.2461 (1.052-1.539)	1.2411 (1.047-1.533)
IV	2.1261 (1.758-3.119)	2.2531 (1.827-3.284)	2.5301 (2.376-2.713)	2.5261 (2.372-2.708)
Lauren classification
Intestinal type	1.00		1.00	1.00
Diffuse type	1.1311 (1.012-1.358)		1.3071 (1.154-1.528)	1.3021 (1.148-1.523)
pT stage
pT1	1.00	1.00	1.00	1.00
pT2	1.8511 (1.431-2.394)	1.9711 (1.528-2.542)	1.1951 (1.102-1.297)	1.1931 (1.100-1.294)
pT3	1.9811 (1.511-2.598)	2.191 (1.678-2.858)	1.4281 (1.328-1.527)	1.4231 (1.324-1.522)
pT4	2.3441 (1.699-3.235)	2.5011 (1.821-3.435)	1.7061 (1.557-1.855)	1.6971 (1.549-1.847)
Total dissected nodes	0.9871 (0.981-0.993)		0.9881 (0.982-0.993)
pN stage
pN0	1.00	1.00	1.00	1.00
pN1	1.2811 (1.123-1.461)	1.2661 (1.11-1.444)	1.5071 (1.393-1.620)	1.5001 (1.387-1.622)
pN2	2.1391 (1.783-2.566)	2.0951 (1.749-2.51)	2.2711 (2.151-2.391)	2.2501 (2.130-2.370)
pN3	3.241 (2.446-4.292)	3.3251 (2.52-4.386)	3.4221 (3.242-3.602)	3.3751 (3.196-3.554)

¹Statistically significant (< 0.05); HR: Hazard radio; CI: Confidence interval; AIC: Akaike Information Criterion.