miRNA studies in in vitro and in vivo activated hepatic stellate cells

Figure 4 Predicted targets of all differentially regulated miRNAs during in vitro activation of primary hepatic stellate cells (Table 1) were analyzed. The two charts represent the enrichment of molecules in affected pathways for the upregulated (A) and downregulated (B) miRNAs. Only pathways with P≤ 0.001 are shown. IGF-1: Insulin-like growth factor-1; ERK: Extracellular signal-regulated kinase; MAPK: Mitogen-activated protein kinase; BMP: Bone morphogenetic protein; IL: Interleukin; ROS: Reactive oxygen species; AMPK: AMP activated protein kinase; TGF: Transforming growth factor; PTEN: Phosphatase and tensin homolog; LXR: Liver X receptor; RXR: Retinoid X receptor; PPAR: Peroxisome proliferator-activated receptor; HGF: Hepatocyte growth factor.