Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice

Figure 2 Liver histology of all groups 24 h after acetaminophen treatment (350 mg/kg). Hematoxylin-eosin-stained liver sections displayed representative hepatocellular morphological changes. Original magnification × 200. A: Liver section in the vehicle control group showed a normal lobular structure; B: Liver section in acetaminophen alone group showed large areas of centrilobular necrosis, vacuolar degeneration and inflammatory cell infiltration; C: Liver section in the 200 mg/kg group showed necrosis with the same degree as in acetaminophen group; D: Liver section in the 400 mg/kg group showed a significant alleviation of liver injury; E: Liver section in the 800 mg/kg group showed absence of necrosis and almost normal lobular structure.