Diagnosis of gastric epithelial neoplasia: Dilemma for Korean pathologists

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Jun 7, 2011 (publication date) through Nov 23, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2011; 17(21): 2602-2610
Published online Jun 7, 2011. doi: 10.3748/wjg.v17.i21.2602

Table 2 Differentiation of low and high grade dysplasia and gastric carcinomas

Histology	Feature	Low-grade dysplasia	High-grade dysplsia	Carcinoma
Structural atypia	Gland size	Uniform	Variable	Variable
	Gland arrangement	Regular	Slightly irregular	Irregular
	Glandular crowding	Slight	Moderate	Marked
	Glandular transition to surrounding mucosa	No	No	No
	Glandular branching/budding	Focal	Prominent	Prominent
	Glandular cribriform	No	Yes	Yes
	Surface maturation	No	No	No
Nuclear atypia	Shape	Elongated	Elongated and/or irregular	Oval/round
	Pseudostratification	Basal 1/2	Over basal 1/2	Irregular
	Membrane	Thin	Thick	Uneven
	Hyperchromasia	Hyperchromatic even	Hyperchromatic irregular	Vesicular
	Pleomorphism	No	Mild	Moderate to marked
	Prominent nucleoli	Absent	Present	Present
	Loss of polarity	No	No/yes	Yes
Stroma	Invasion	No	No	Yes

Citation: Kim JM, Cho MY, Sohn JH, Kang DY, Park CK, Kim WH, Jin SY, Kim KM, Chang HK, Yu E, Jung ES, Chang MS, Joo JE, Joo M, Kim YW, Park DY, Kang YK, Park SH, Han HS, Kim YB, Park HS, Chae YS, Kwon KW, Chang HJ, Pathologists TGPSGOKSO. Diagnosis of gastric epithelial neoplasia: Dilemma for Korean pathologists. World J Gastroenterol 2011; 17(21): 2602-2610
URL: https://www.wjgnet.com/1007-9327/full/v17/i21/2602.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i21.2602