Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients

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May 28, 2011 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2011; 17(20): 2500-2506
Published online May 28, 2011. doi: 10.3748/wjg.v17.i20.2500

Table 1 Common mechanisms of liver/hepatocyte damage

Effect	HIV	HCV	Alcohol	HAART
Increase ROS	√	√	√
Increase proinflammatory cytokines	√	√	√
Oxidative stress	√	√	√	√
Lipid peroxidation	√	√	√
Mitochondrial damage	√	√	√	√
Steatosis	√	√	√	√
Glutathione depletion	√		√	√
Proteasome dysfunction			√	√

HIV: Human immunodeficiency virus; HCV: Hepatitis C virus; HAART: Highly active antiretroviral therapy; ROS: Reactive oxygen species.

Citation: Szabo G, Zakhari S. Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients. World J Gastroenterol 2011; 17(20): 2500-2506
URL: https://www.wjgnet.com/1007-9327/full/v17/i20/2500.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i20.2500