LY294002 potentiates the anti-cancer effect of oxaliplatin for gastric cancer via death receptor pathway

Figure 5 Effects of oxaliplatin, LY294002, or combination on in vivo tumor growth and apoptosis. A: Tumor volumes of nude mice in each group are presented. Each time point represents the mean tumor volume for each group; B: Detection of apoptotic cells in tumor tissue was performed by transferase-mediated dUTP nick end labeling (TUNEL) assay; C: The expression of phospho-AktSer⁴⁷³, nuclear factor κB (NFκB)-p65, Fas ligand (FasL), short form of cellular caspase-8/FLICE-inhibitory protein (c-FLIP_S), Bid, caspase-8, and caspase-3 was investigated by immunohistochemical analysis.