Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors

Table 3 Microvessel density scores in gastroenteropancreatic neuroendocrine tumors in relation to clinicopathological parameters

	MVD-endoglin				MVD-CD31
	n	mean1	SE1	P	n	mean1	SE1	P
Tumor type
Carcinoid	11	55	107	0.30	13	123	23	0.75
Functional PNET	24	65	8		23	106	18
Non-functional PNET	14	85	18		14	100	17
Origin
Primary tumors	36	66	8	0.58	37	111	13	0.69
Metastatic tumors	13	75	15		13	101	24
WHO classification
Well-differentiated NETs	13	69	18	0.932	13	76	12	0.082
Well-differentiated NECs	33	67	7		34	121	15
Poorly-differentiated NECs	1	212			1	82
Primary tumors: metastases
Present	19	66	9	0.96	20	138	18	0.053
Absent	17	67	14		17	88	15

¹Values × 1000 pixels per area;

²Result of unpaired t test to compare well-differentiated neuroendocrine tumors (NETs) with well-differentiated neuroendocrine carcinomas (NECs);

³P values are considered statistically significant. MVD: Microvessel density; PNET: Pancreatic neuroendocrine tumor.