Polymorphisms in NF-κB, PXR, LXR, PPARγ and risk of inflammatory bowel disease

Table 6 Published associations between pregnane X receptor polymorphisms and inflammatory bowel disease risk

	Cases	Controls	C-25385T (rs3814055)	A-24381C (rs1523127)	C8055T (rs2276707)	A7635G (rs6785049)
Danish1	822	779		Neg	Neg	Variant	Present study
Irish2	422	336	Wild-type	Wild-type	Variant	Wild-type	Dring et al[47]
Scottish2	715	334		Neg			Ho et al[49]
Spanish2	696	550	Variant		Wild-type		Martínez et al[50]
Canadian3	270	336		Neg		Neg	Amre et al[48]

No association is indicated by “neg”. The risk allele is indicated for positive associations between the pregnane X receptor polymorphisms and inflammatory bowel disease risk.

¹Associations adjusted for smoking status;

²Associations not adjusted for smoking status,

³Children with Crohn’s disease.