Effects of appendectomy and oral tolerance on dextran sulfate sodium colitis

Figure 4 Histological findings in colon-extracted protein- or bovine serum albumin-treated mice in appendectomized (A and B) and sham-operated (C and D) groups. In the appendectomy group, there were similar histological features, massive lymphocyte infiltration, loss of goblet cells, crypt damage, mucosal ulceration, and accompanying submucosal edema, whereas in sham-operated mice, there was less amelioration of colonic inflammation. CEP: Colon-extracted protein; BSA: Bovine serum albumin.