Soluble ST2: A new and promising activity marker in ulcerative colitis

Figure 2 Analysis of serum sST2 and total intestinal ST2 levels in ulcerative colitis patients according to endoscopic and histopathological activity. Distribution of serum sST2 and total intestinal ST2 levels in ulcerative colitis (UC) patients according to the 4 rank Endoscopic Mayo Activity Score (A and C) (Activity: 0 = inactive; 1 = mild; 2 = moderate; 3 = severe) and histopathological score (B and D) (Degree of inflammation: 0 = normal; 1 = mild; 2 = moderate; 3 = severe with active ulceration). Data are represented as median and percentiles (25th-75th). Serum sST2 levels are significantly different among UC patient sub-groups of moderate and severe activity in relation to inactive and mild activity, independent of the score used. Total intestinal ST2 levels directly correlate with endoscopic activity (C) and degree of mucosal inflammation (D). A: ^bP < 0.001, 2 vs 0 and 1; ^dP < 0.001, 3 vs 0 and 1; B: ^bP < 0.01, 2 vs 0 and 1; ^dP < 0.001, 3 vs 0 and 1; C: ^aP < 0.05, 2 vs 1; ^dP < 0.01, 2 vs 0; ^fP < 0.001, 3 vs 0 and 1; D: ^bP < 0.01, 2 vs 1; ^dP < 0.001, 2 vs 0; ^fP < 0.001, 3 vs 0 and 1.