Effects of α-mangostin on apoptosis induction of human colon cancer

Figure 10 A proposed diagram for α-mangostin-induced apoptosis in COLO 205 cells. Upon α-mangostin treatment, extrinsic pathway was activated, procaspase-8 was cleaved to caspase-8 which then further activated the cleavage of Bid to t-Bid. The t-Bid then translocates to mitochondria resulting in the activation of mitochondrial apoptotic pathway.