DEC1 nuclear expression: A marker of differentiation grade in hepatocellular carcinoma

Figure 1 Differentiated embryo chondrocyte 1 expression in normal liver tissue by immunohistochemical staining. A: Normal liver tissues showing strong nuclear differentiated embryo chondrocyte 1 (DEC1) staining and diffuse cytoplasmic staining in hepatocytes, × 400; B: Strong granular staining of DEC1 in cytoplasm of hepatocytes around the central vein in the intact hepatic lobule, × 200; C: Absent granular staining and diffuse DEC1 staining pattern around portal area, × 400; D: Liver mesenchymal tissues, × 400. Endothelial cells (single arrow) and bile duct epithelial cells (double arrow) showing cytoplasm and/or nuclear DEC1 immunoreactivity.