Down-regulation of miR-622 in gastric cancer promotes cellular invasion and tumor metastasis by targeting ING1 gene

Figure 3 MiR-622 promotes tumorigenesis and metastasis in vivo. A: Photographs of tumors in nude mice resulting from injection of miR-622 expression vector (pS-miR-622) or control plasmid (pS-control) stably transfected SGC-7901 cells; B: Tumorigenesis curves. Rapid tumor growth was observed in the pS-miR-622 group (data expressed as mean ± SD; P < 0.05); C: Photographs of the number of liver metastatic nodes in nude mice injected with pS-miR-622 or pS-control vector stably transfected SGC-7901 cells. The arrows indicate liver metastatic nodes; D: Histological examination found that the expression of ING1 was markedly reduced in the pS-miR-622-transfection group compared with the control groups. ^aP < 0.05, compared with miR-control transfectants. Scale bars: 200 μm. pS-control: Control plasmid; pS-miR-622: miR-622 expression vector.