Clinicopathologic significance of GLUT1 expression and its correlation with Apaf-1 in colorectal adenocarcinomas

Table 3 Survival analyses of variables predicting the risk of death with colorectal adenocarcinomas

Variables	Significance univariate1	Significance multivariate2	Hazard ratio	95% CI
Overall survival
GLUT1 expression (< 50% vs≥ 50%)	0.047	0.534	1.101	0.813-1.491
Patient age (< 58 yr vs≥ 58 yr)	< 0.001	< 0.001	1.884	1.389-2.555
Differentiation (low vs high)	< 0.001	< 0.001	1.846	1.344-2.536
AJCC stage (0, I, II vs III, IV)	< 0.001	< 0.001	2.715	1.909-3.863
Vascular invasion (absent vs present)	0.001	0.005	2.993	1.393-6.430
Disease free survival
GLUT1 expression (< 50% vs≥ 50%)	0.021	0.416	1.118	0.855-1.461
Patient age (< 58 yr vs≥ 58 yr)	0.002	0.003	1.497	1.150-1.947
Differentiation (low vs high)	< 0.001	0.002	1.593	1.193-2.126
AJCC stage (0, I, II vs III, IV)	< 0.001	< 0.001	2.940	2.161-3.999
Vascular invasion (absent vs present)	0.014	0.035	2.264	1.057-4.848

¹Log-rank test;

²Cox proportional hazards model. GLUT1: Glucose transporter 1; CI: Confidence interval.