Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy

Table 1 Frequency scale for the symptoms of gastroesophageal reflux disease

	Question	Never	Occasionally	Sometimes	Often	Always
1	Do you get heartburn?	0	1	2	3	4
2	Does your stomach get bloated?	0	1	2	3	4
3	Does your stomach ever feel heavy after meals?	0	1	2	3	4
4	Do you sometimes subconsciously rub your chest with your hand?	0	1	2	3	4
5	Do you ever feel sick after meals?	0	1	2	3	4
6	Do you get heartburn after meals?	0	1	2	3	4
7	Do you have an unusual (e.g. burning) sensation in your throat?	0	1	2	3	4
8	Do you feel full while eating meals?	0	1	2	3	4
9	Do some things get stuck when you swallow?	0	1	2	3	4
10	Do you get bitter liquid (acid) coming up into your throat?	0	1	2	3	4
11	Do you burp a lot?	0	1	2	3	4
12	Do you get heartburn if you bend over?	0	1	2	3	4

Patients were asked to score each question as never = 0; occasionally = 1; sometimes = 2; often = 3; or always = 4. In the frequency scale for the symptoms of gastroesophageal reflux disease (FSSG) , there are seven acid-reflux-related symptoms (questions 1, 4, 6, 7, 9, 10 and 12), and five dysmotility-like symptoms (questions 2, 3, 5, 8 and 11). The acid reflux, dysmotility and total scores (acid reflux and dysmotility scores) were calculated, and a total score of ≥ 8 was considered to indicate probable GERD/NERD.