Omeprazole decreases magnesium transport across Caco-2 monolayers

Figure 1 Mg_A→B transport across Caco-2 monolayers. For Mg_A→B transport of 14 d monolayers, A: Control; B: 200 ng/mL omeprazole-treated; C: 400 ng/mL omeprazole-treated; D: 600 ng/mL omeprazole-treated; E: 800 ng/mL omeprazole-treated; and F: 1000 ng/mL omeprazole-treated monolayers. For Mg_A→B transport of 21 d monolayers, G: control; H: 200 ng/mL omeprazole-treated; I: 400 ng/mL omeprazole-treated; J: 600 ng/mL omeprazole-treated; K: 800 ng/mL omeprazole-treated and L: 1000 ng/mL omeprazole-treated monolayers. Light solid lines represent the saturable component. Dashed lines represent the non-saturable component. ^aP < 0.05, ^bP < 0.01, ^dP < 0.001 vs the age-matched control group, ^cP < 0.05, ^fP < 0.01, ^hP < 0.001 vs the concentration-matched 14 d omeprazole-treated groups. For each data point, n = 9.