Glutamate reduces experimental intestinal hyperpermeability and facilitates glutamine support of gut integrity

Figure 1 Model illustrating intestinal cell lineage with tight junctions and EAAT transporter. The extracellular enzymatic conversion of glutamine to glutamate by γ-glutamyltransferase (γ-GT) is shown on the apical side. The experimental design of the study using the γ-GT blocking enzyme, acivicin, and the blocker of the glutamate transporter, EAAT L-trans-pyrrolidine-2,4-dicarboxylic, is included in the figure.