Potential beneficial effects of butyrate in intestinal and extraintestinal diseases

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Mar 28, 2011 (publication date) through Feb 8, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 28, 2011; 17(12): 1519-1528
Published online Mar 28, 2011. doi: 10.3748/wjg.v17.i12.1519

Table 1 Main butyrate effects potentially useful in human medicine

Intestinal level	Extraintestinal level
Ion absorption	Insulin sensitivity
Cell proliferation	Cholesterol synthesis
Cell differentation	Energy expenditure
Intestinal barrier function	Ammonia scavenger
Immune-regulation	Stimulation of β-oxidation of very long chain fatty acids and peroxisome proliferation
Oxidative stress	CFTR function
Intestinal motility	Neurogenesis
Visceral perception and rectal compliance	HbF production

CFTR: Cystic fibrosis transmembrane conductance regulator; HbF: Butyrate to increase fetal hemoglobin.

Citation: Canani RB, Costanzo MD, Leone L, Pedata M, Meli R, Calignano A. Potential beneficial effects of butyrate in intestinal and extraintestinal diseases. World J Gastroenterol 2011; 17(12): 1519-1528
URL: https://www.wjgnet.com/1007-9327/full/v17/i12/1519.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i12.1519