Proton pump inhibitor step-down therapy for GERD: A multi-center study in Japan

Table 3 Predictors of successful step-down (univariate analysis)

Variable	ITT population(n = 83)		PP population(n = 70)
	OR	P	OR	P
Age	0.984	0.428	0.965	0.212
BMI	3.667	0.073	2.108	0.251
Past history of treatment for GERD	0.497	0.161	0.228	0.019
Duration of GERD symptoms	1.004	0.416	1.199	0.536
Alcohol use	1.182	0.732	1.486	0.487
Tobacco use	1.125	0.834	0.692	0.531
Helicobacter pylori infection	0.963	0.942	1.500	0.577
Erosive esophagitis	2.599	0.062	1.402	0.620
LA classification	1.431	0.070	1.238	0.360
Atrophic gastritis	0.930	0.906	0.568	0.411
Hiatus hernia	1.333	0.566	1.476	0.545
complete remission of GERD symptoms before step-down	1.355	0.539	3.676	0.042
GSRS total score (at the beginning of step-down)	0.771	0.647	0.208	0.045
Reflux score in GSRS (at the beginning of step-down)	0.917	0.803	0.477	0.072
Indigestion score in GSRS (at the beginning of step-down)	0.594	0.209	0.218	0.011

BMI: Body mass index; GERD: Gastroesophageal reflux disease; GSRS: Gastrointestinal Symptom Rating Scale; ITT: Intention-to-treat; PP: Per-protocol; OR: Odds ratio; LA: Los Angeles.