Hepatitis B virus infection: A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection

Table 6 Univariate and multivariate analyses of prognostic factors for survival of intrahepatic cholangiocarcinoma patients without hepatitis B virus infection.

Factor	n	No HBV infection		P value		Hazard ratio	95% CI
		1-yr (%)	3-yr (%)	Univariate analysis	Multivariate analyses
Hepatolithiasis
Yes	10	10.0	< 0.01
No	58	51.7	24.1	0.013	0.084	2.979	0.900-5.223
r-GT
≤ 64 U/L	30	56.7	36.4
> 64 U/L	38	36.8	7.9	0.001	0.041	4.157	1.035-5.614
ALP
≤ 119 U/L	35	51.4	31.4
> 119 U/L	33	39.4	9.1	0.017	0.407	0.688	0.316-1.595
CA19-9
≤ 37 U/mL	23	60.9	43.5
> 37 U/mL	45	37.8	8.9	0.001	0.173	1.858	0.806-3.311
Tumor number
Single	60	48.3	23.2
Multiple	8	25.0	< 0.01	0.050	0.392	0.734	0.609-3.540
Tumor size
< 5 cm	20	50.0	24.0
≥ 5 cm	48	43.8	18.8	0.308	NA	NA	NA
Tumor location
Left lobe	27	40.7	21.6
Right lobe	36	55.6	22.2
Both lobes	5	< 0.01	< 0.01	0.137	NA	NA	NA
Microscopic satellite lesion
Yes	16	31.2	< 0.01
No	52	50.0	26.9	0.003	0.015	5.956	1.183-4.657
Tumor differentiation
Well to moderately	52	50.0	24.9
Poorly	16	31.2	6.2	0.076	0.016	5.844	1.172-4.569
Vascular invasion
Yes	13	53.8	30.8
No	55	43.6	18.0	0.459	NA	NA	NA
Lymphatic metastasis
Yes	20	25.0	5.0
No	48	54.2	26.9	0.015	0.430	0.624	0.683-2.452
Extrahepatic metastasis
Yes	5	< 0.01	< 0.01
No	63	49.2	22.1	< 0.001	0.065	3.403	0.933-9.940

NA: Not applicable; ALP: Alkaline phosphatase; r-GT: R-glutamyltransferase; CA 19-9: Carbohydrate antigen 19-9.