Hepatitis B virus infection: A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection

doi:10.3748/wjg.v17.i10.1292

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Mar 14, 2011 (publication date) through Feb 11, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 14, 2011; 17(10): 1292-1303
Published online Mar 14, 2011. doi: 10.3748/wjg.v17.i10.1292

Table 4 Clinicopathological features of intrahepatic cholangiocarcinoma patients according to their hepatitis B virus infection

	HBV infection		P value
	Yes (n = 87)	No (n = 68)	P value
Gender (M/F)	64/23	38/30	0.021
Age (> 65 yr) (%)	17 (19.54)	13 (14.94)	0.763
Hepatolithiasis (%)	2 (2.30)	10 (14.71)	0.004
Hepatic schistosomiasis (%)	2 (2.30)	5 (7.35)	0.133
ALT (> 42 U/L) (%)	27 (34.03)	15 (22.06)	0.212
AST (> 37 U/L) (%)	38 (43.68)	15(22.06)	0.005
TBIL (> 20 μmol/L) (%)	20 (22.99)	16 (23.53)	0.937
r-GT (> 64 U/L) (%)	49 (56.32)	38 (55.88)	0.956
ALP(> 119 U/L) (%)	33 (37.93)	33 (48.53)	0.185
AFP (> 20 μg/L) (%)	25 (28.74)	5 (7.35)	0.001
CA19-9 (> 37 U/mL) (%)	44 (50.57)	45 (66.18)	0.051
CA19-9 (> 200 U/mL) (%)	20 (22.99)	32 (47.06)	0.002
Tumor location (%)			0.520
Left lobe	28 (32.18)	27 (39.71)
Right lobe	54 (62.07)	36 (52.94)
Both lobes	5 (5.75)	5 (7.35)
Tumor size
< 5 cm	38 (43.68)	20 (29.41)	0.069
≥ 5 cm	49 (56.32)	48 (70.59)
Tumor number (%)			0.958
Single	77 (88.51)	60 (88.24)
Multiple	10 (11.49)	8 (11.76)
Histological inflammation (%)	35 (40.23)	4 (11.76)	< 0.001
Cirrhosis (%)	40 (45.98)	5 (7.35)	< 0.001
Capsule formation (%)	15 (17.24)	2 (2.41)	0.005
Tumor differentiation (%)			0.036
Well	0 (< 0.01)	5 (7.35)
Moderately	66 (75.86)	47 (69.12)
Poorly	21 (24.14)	16 (23.53)
Vascular invasion (%)	22 (25.29)	13 (19.12)	0.362
Perineural infiltration (%)	0 (< 0.01)	3 (4.41)	0.082
Microscopic satellite lesion (%)	23 (26.44)	16 (23.53)	0.679
Lymphatic metastasis (%)	12 (13.79)	20 (29.41)	0.017
Extrahepatic metastasis (%)	5 (5.75)	5 (7.35)	0.749
Immunohistochemical examinations
CK18 positive staining (%) (n = 135)¹	78 (89.66)	57 (86.36)	0.531
CK19 positive staining (%) (n = 139)¹	75 (86.21)	64 (96.97)	0.022

¹Number of available data. HBV: Hepatitis B virus; M: Male; F: Female; TBIL: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; AFP: α-fetoprotein; ALP: Alkaline phosphatase; r-GT: R-glutamyltransferase; CA19-9: Carbohydrate antigen 19-9; CK: Cytokeratin.

Citation: Zhou HB, Wang H, Li YQ, Li SX, Wang H, Zhou DX, Tu QQ, Wang Q, Zou SS, Wu MC, Hu HP. Hepatitis B virus infection: A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection. World J Gastroenterol 2011; 17(10): 1292-1303
URL: https://www.wjgnet.com/1007-9327/full/v17/i10/1292.htm
DOI: https://dx.doi.org/10.3748/wjg.v17.i10.1292