Endocrine impact of Helicobacter pylori: Focus on ghrelin and ghrelin o-acyltransferase

Table 2 Original studies measuring the effect of H. pylori infection on plasma acyl and unacylated ghrelin levels

Subjects	Nationality	Tissue	Acyl and total ghrelin in H. pylori infection (or cure)	Ref.
69 Adults F + M	Japanese	P	↓ acyl ghrl in atrophy only	[98]
50 Adults F + M	Italian	P	↑ acyl ghrl and acyl/total ratio in atrophy cf. healthy controls	[63]
220 Adults F + M	Japanese	P	↓ acyl ghrl associated with atrophy and ↑ after cure	[62]

F: Female; M: Male; P: Plasma; Ghrl: Ghrelin; ↑: Increased; ↓: Decreased.