MiRNA profile in esophageal squamous cell carcinoma: Downregulation of miR-143 and miR-145

Table 3 miR-143 and miR-145 predicted targets related to cell mobility

	Predicted targets	Functions
miR-143	LASP1 (LIM and SH3 protein 1)	Functions as an actin-binding protein and possibly in cytoskeletal organization
	RICTOR (RPTOR independent companion of MTOR, complex 2)	Functions upstream of Rho GTPases to regulate the actin cytoskeleton
	ARHGAP26 (Rho GTPase activating protein 26)	Regulates the organization of the actin-cytoskeleton
	EPB41 [erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked)]	Together with spectrin and actin, constitute the red cell membrane cytoskeletal network.
	MYO3A (myosin IIIA)	Belongs to the myosin superfamily, an actin-dependent motor protein
	MARCKS (myristoylated alanine-rich protein kinase C substrate)	An actin filament crosslinking protein involved in cell motility
	SVIL (supervillin)	Tightly associated with both actin filaments and plasma membranes
miR-145	ARF6 (ADP-ribosylation factor 6)	Regulates vesicular trafficking, remodeling of membrane lipids, and signaling pathways that lead to actin remodeling.
	ABLIM2 (actin binding LIM protein family, member 2)	Bound strongly to F-actin, localized to actin stress fibers
	ADD3 [adducin 3 (γ)]	Involved in assembly of the spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues
	CAPZB (c apping protein (actin filament) muscle Z-line, β)	Regulates growth of the actin filament by capping the barbed end of growing actin filaments.
	ELMO1 (engulfment and cell motility 1)	Mediates cytoskeletal rearrangements during phagocytosis of apoptotic cells and cell motility
	PHACTR2 (phosphatase and actin regulator 2)	Coprecipitated with both PP1 and actin
	TMOD1 (tropomodulin 1)	Inhibits depolymerization and elongation of the pointed end of actin filaments