Omeprazole induces gastric transmucosal permeability to the peptide bradykinin

Figure 2 Effect of 200 μmol/L omeprazole on 10 μmol/L ¹⁴C-EDTA flux rate across rat corpus mucosa. The flux rate of ¹⁴C-EDTA dramatically increases over time after the addition of omeprazole compared to the DMSO vehicle control. Representative of three experiments and three separate animals. Samples were taken at 15 min intervals beginning at 30 min after the addition of the isotope. Omeprazole and DMSO were added to their respective chambers 75 min after the addition of ¹⁴C-EDTA. The total flux time was 135 min. ¹⁴C-EDTA was added to the serosal fluid compartment and samples were taken from the mucosal fluid compartment.