Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs

Figure 7 Heparin and staurosporine prevented CCK-8S-intensified I_Ca-L in PCSMCs. A: Current traces of I_Ca-L were evoked by a step from -40 mV to +10 mV. When heparin (10^-6 mol/L) was present in the pipette solution, CCK-8S (10^-7 mol/L) did not increase I_BKCa; CCK-8S (10^-7 mol/L) failed to increase I_BKCa in the presence of staurosporine (10^-6 mol/L); B: CCK-8S-induced enhancement of I_Ca-L in the absence and presence of staurosporine and heparin, respectively. ^aP < 0.05 vs CCK-8S group.