Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs

Figure 4 Effects of CCK-8S on I_BKCa of PCSMCs. A: Current traces of I_BKCa were recorded from -60 mV to +100 mV during 400 ms depolarization; B: CCK-8S increased I_BKCa in a concentration-dependent manner (EC₅₀ = 3.5 × 10^-8 mol/L); CCK-8S (10^-7 mol/L) enhanced I_BKCa depolarized from -60 mV to +60 mV (from 916 ± 183 pA to 1088 ± 226 pA; n = 8, P < 0.01); C: Current-voltage relationship of average peak I_BKCa under each condition. CCK-8S-evoked enhancement of I_BKCa was suppressed by devazepide (10^-7 mol/L). ^aP < 0.05 vs control group (CaPSS).