Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs

Figure 2 Effects of CCK-8S on resting potential (RP) of PCSMCs. RP rose from -61.3 ± 2.7 mV to -29.8 ± 5.9 mV after superfusion with CCK-8S (10^-7 mol/L). In the presence of devazepide (10^-7 mol/L), CCK-8S (10^-7 mol/L) did not depolarize RP (-59.4 ± 3.8 mV). When SMCs were pretreated with CI 988, CCK-8S (10^-7 mol/L) depolarized RP to -29.8 ± 5.9 mV. ^aP < 0.01 vs control group (CaPSS).