Mechanisms mediating CCK-8S-induced contraction of proximal colon in guinea pigs

Table 1 Effects of CCK-8S on the contractile amplitude and frequency of CM and LM strips of proximal colon (mean ± SD)

	CM strips		LM strips
	Amplitude	Frequency	Amplitude	Frequency
CCK-8S	56.53 ± 11.92a	0.87 ± 1.52	65.93 ± 12.98a	31.69 ± 13.58a
Devazepide + CCK-8S	3.68 ± 1.17	1.92 ± 0.83	2.09 ± 0.78	1.57 ± 1.07
Nifedipine + CCK-8S	-79.26 ± 5.93c	-19.82 ± 3.92c	-78.69 ± 6.42c	-21.58 ± 2.87c
Iberiotoxin + CCK-8S	49.93 ± 11.81	-36.57 ± 17.35c	57.47 ± 10.92	-23.82 ± 5.97c
TG & BA + CCK-8S	-98.12 ± 0.72d	-97.42 ± 2.73d	-97.57 ± 1.25d	-96.11 ± 3.26d
CI 988 + CCK-8S	53.29 ± 0.52	1.48 ± 0.17	57.48 ± 11.27	28.96 ± 9.53

^aP < 0.05 vs control group;

^cP < 0.05,

^dP < 0.01 vs CCK-8S group. CCK: Cholecystokinin; CM: Circular muscle; LM: Longitudinal muscle; TG: Thapsigargin; BA: BAPTA-AM.