Prognosis and feasibility of en-bloc vascular resection in stage II pancreatic adenocarcinoma

Table 3 Univariate analyses of predictive factors for survival of patients with stage II adenocarcinoma of the pancreas after PD or PPPD, with or without vascular resection

Parameters	Median (mo)	95% CI of median	3-yr survival (%)	P value
Age (yr)				0.852
≤ 70 (n = 62)	11.51	7.78-15.25	12.0
> 70 (n = 23)	9.40	9.15-9.65	16.3
Sex				0.191
Male (n = 55)	9.76	7.61-11.91	9.6
Female (n = 30)	14.01	3.20-24.82	19.4
Albumin (g/dL)				0.107
≤ 3.5 (n = 21)	7.40	3.86-10.94	12.7
> 3.5 (n = 47)	11.67	5.96-17.38	12.8
Total bilirubin (mg/dL)				0.008
≤ 2 (n = 19)	17.39	15.23-19.55	30.7
> 2 (n = 65)	9.40	7.66-11.14	3.5
Serum CA 19-9 (U/L)				0.167
≤ 37 (n = 16)	16.11	1.47-30.75	25.0
> 37 (n = 54)	11.51	8.17-14.85	12.3
Serum CEA (ng/mL)				0.455
≤ 5 (n = 40)	16.08	10.78-21.38	13.4
> 5 (n = 24)	7.82	5.18-10.46.	16.7
Blood transfusion				0.491
Yes (n = 47)	10.88	7.17-14.59	14.9
No (n = 38)	9.24	5.59-12.89	9.8
Tumor size (cm)
≤ 3 (n = 43)	13.97	10.77-17.18	13.3	0.508
> 3 (n = 41)	9.27	8.82-9.72	12.5
Nodal metastases				0.557
Yes (n = 71)	9.76	7.69-11.83	13.6
No (n = 14)	12.16	0.00-28.36	8.3
Pre-op biliary drainage				0.262
Yes (n = 49)	9.24	7.80-10.68	12.0
No (n = 36)	13.97	9.44-18.50	14.3
PV/SMV resection				0.994
Yes (n = 12)	9.27	0.00-19.54	16.7
No (n = 73)	10.36	7.87-12.86	12.2
Resection margin1				0.071
Negative (n = 58)	11.51	6.46-16.56	16.1
Positive (n = 27)	9.27	7.46-11.08	5.1
Differentiation				0.016
Well (n = 25)	20.98	9.02-32.94	24.0
Moderately (n = 45)	8.81	7.81-9.81	8.8
Poorly (n = 15)	10.49	7.01-13.97	6.7
Adjuvant chemotherapy				0.008
Yes (n = 53)	12.99	10.44-12.74	18.8
No (n = 32)	7.96	5.74-10.19	3.2

Two cases of mortality were not included in survival analysis.

¹Resection margin was negative in all 12 patients who underwent vascular resection.