Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis

doi:10.3748/wjg.v16.i8.973

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Feb 28, 2010 (publication date) through Feb 21, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 28, 2010; 16(8): 973-981
Published online Feb 28, 2010. doi: 10.3748/wjg.v16.i8.973

Table 4 Reactivity of sera from 95 anti-M2 positive PBC patients with different peptide conjugates containing the reported immunodominant epitope of PDC-E2[6,12]

Peptides of the inner lipoyl domain	IgG-antibodies			IgM-antibodies
Peptides of the inner lipoyl domain	Positive n (%)	mean absorbance × 1000 ± SD (median)	Cut off value	Positive n (%)	mean absorbance × 1000 ± SD (median)	Cut off value
152-176 (present study peptide 10)	28 (29)	153 ± 243 (87)	150	35 (37)	95 ± 77 (73)	80
169-193 (present study peptide 11)	11 (12)	210 ± 219 (157)	300	37 (39)	143 ± 120 (101)	120
167-184	0	113 ± 63 (93)	100	5 (5)	53 ± 79 (20)	100
167-184-LA	3 (3)	135 ± 71 (111)	100	10 (11)	78 ± 107 (40)	100
OVA-167-184¹	42 (44)	316 ± 260 (271)	100	54 (57)	254 ± 318 (117)	100
OVA-167-184-LA¹	21 (22)	175 ± 280 (148)	100	29 (31)	113 ± 217 (52)	100

¹After subtraction of reactivity to OVA alone.

Citation: Braun S, Berg C, Buck S, Gregor M, Klein R. Catalytic domain of PDC-E2 contains epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis. World J Gastroenterol 2010; 16(8): 973-981
URL: https://www.wjgnet.com/1007-9327/full/v16/i8/973.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i8.973