Analgesic effects of JCM-16021 on neonatal maternal separation-induced visceral pain in rats

Figure 4 JCM-16021 effect on enterochromaffin cell number (Chr A positive cell number) in the colons of rats. Chr A staining cells (arrows) are present in colon tissues in the normal control group (A), the NMS control group (B), the NMS with high dosage (C), the NMS with middle dosage (D), and the NMS with low dosage of JCM-16021 (E). NMS significantly increased the number of Chr A positive cells in the colons of rats, and JCM-16021 did not change the number of Chr A positive cells (F). Data are presented as mean ± SE (n = 8-10). Significant difference is indicated by ^aP < 0.05 compared with the normal control group.