Treatment of hepatitis B virus-associated glomerulonephritis: A meta-analysis

Table 3 Design of 5 clinical trials on efficacy of corticosteroid therapy for HBV-GN

Author	Group	Case (n)	Intervention	Dropped-out (n)	Outcome		Follow-up
					CR	Renal insufficiency (n)
Lai et al[22], 1990	Control	7	Diuretic agents	0	2 complete remission	UA	14-37 mo
	Treatment	8	Prednisolone 60 mg/d (adult), 40 mg/m2 per day (< 15 yr), for 6 mo	0	3 complete remission, 4 partial remission, 1 relapse	UA
Ozdamar et al[23], 2003	Control	4	None	0	4 complete remission	UA	5-120 mo
	Treatment	8	Prednisolone, 2 mg/kg per day	2	1 complete remission, 4 partial remission, 1 death due to sepsis	UA
Panomsak et al[20], 2006	Control	10	ACEI, fish oil, or neither	3	2 complete remission	2 ESRD	5-120 mo
	Treatment	6	Prednisolone, 2 mg/kg per day	1	3 complete remission, 2 partial remission	0
Yang et al[21], 2003	Control	14	The same supportive and symptomatic treatment as treatment group	0	9 complete remission, 2 partial remission	0	3.8 ± 2.4 yr
	Treatment	8	Prednisolone, 1.5-2 mg/kg per day, for 3 mo	0	4 complete remission, 2 partial remission	0
Peña et al[24], 2001	Control	4	Symptomatic treatment	0	4 complete remission	UA	9.95 ± 5.88 yr
	Treatment	7	Prednisone, 1.5-2 mg/kg per day, a minimun of 4 wk (1 case prednisone + CTX)	0	7 steroid-resistant during therapy, but all complete remission at the end of follow-up	UA

CTX: Cytoxan.