Recent developments in palliative chemotherapy for locally advanced and metastatic pancreas cancer

Table 2 Phase III trials of gemcitabine doublets

Phase III trial	Combination	OS (mo)	P	PFS (mo)	P
Berlin et al[12] (n = 322)	Gem + FU	6.7	0.09	3.4	0.022
	Gem	5.4		2.2
Herrmann et al[16] (n = 319)	Gem + Cap	8.4	0.234	4.8	0.0207
	Gem	7.2		4.0
Heinemann et al[19] (n = 219)	Gem + Cisplatin	7.6	0.12	5.3	0.053
	Gem	6.0		3.1
Colucci et al[20] (n = 107)	Gem + Cisplatin	6.9	0.48	5	0.048
	Gem	4.6		2
Louvet et al[23] (n = 326)	GemOx	9.0	0.13	5.8	0.04
	Gem	7.1		3.7
Poplin et al[11] (n = 824)	GemOx	5.7	0.09	2.7	0.15
	Gem	4.9		2.6
	Gem FDR	6.2		3.5
Rocha Lima et al[27] (n = 342)	IRINOGEM	6.3	0.789	3.5	0.352
	Gem	6.6		3.0
O'Reilly et al[29] (n = 339)	Gem + Exatecan	6.7	0.52	3.9	0.22
	Gem	6.2		4.0

FU: Fluorouracil.