A focus on parietal cells as a renewing cell population

Figure 2 Diagram summarizing the origin and differentiation program of parietal cells. The stem cell either directly or indirectly (via prepit or preneck cells) give rise to the committed progenitors of parietal cells (preparietal cells). Preparietal cells evolve in 4 successive stages (2 are depicted here) to become mature parietal cells. Preparietal cell 1 is characterized by long microvilli and preparietal cell 2 by an incipient canaliculus which expands around the nucleus in the mature parietal cell.