DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China

Table 3 Analysis of genes genotype in ESCC carcinogenesis n (%)

Gene/genotype	Control (n = 326)	Cases (n = 128)	OR (95% CI)	P value
ALDH2
Rs886205
TT	40 (12.270)	5 (3.906)	1.0 (reference)
CT	114 (34.969)	56 (43.750)	3.930 (1.470-10.504)	0.004
CC	172 (52.761)	67 (52.344)	3.116 (1.179-8.234)	0.017
MGMT
Rs11016878
AA	18 (5.522)	15 (11.719)	1.0 (reference)
AG	130 (39.877)	42 (32.815)	0.388 (0.180-0.836)	0.013
GG	178 (54.601)	71 (55.466)	0.479 (0.229-1.002)	0.047
Rs11016879
GG	118 (36.196)	17 (13.281)	1.0 (reference)
AG	150 (46.012)	85 (66.406)	3.933 (2.216-6.982)	0.000
AA	58 (17.791)	26 (20.313)	3.112 (1.565-6.181)	0.001
Rs7069143
CC	87 (26.687)	54 (42.188)	1.0 (reference)
CT	182 (55.828)	54 (42.188)	0.478 (0.303-0.754)	0.001
TT	57 (17.485)	20 (15.625)	0.565 (0.306-1.043)	0.066
Rs12771882
GG	181 (55.521)	63 (49.219)	1.0 (reference)
AG	125 (38.344)	48 (37.500)	1.013 (0.711-1.712)	0.661
AA	20 (6.350)	17 (13.281)	2.442 (1.204-4.595)	0.011
Rs7075748
CC	88 (26.994)	22 (17.188)	1.0 (reference)
CT	156 (47.853)	76 (59.375)	1.949 (1.134-3.350)	0.015
TT	82 (25.153)	30 (23.438)	1.463 (0.782-2.740)	0.233
Rs7071825
AA	46	24	1.0 (reference)
AG	144	69	0.918 (0.519-1.625)	0.770
GG	136	35	0.493 (0.266-0.915)	0.024