Significance and relationship between Cripto-1 and p-STAT3 expression in gastric cancer and precancerous lesions

Table 3 Correlation between CR-1 expression and clinicopathological features of GC

Groups	n	Cripto-1 expression				+→+++ (%)	χ²	P
		-	+	++	+++
Gender							4.052	0.269
Female	57	11	24	14	8	80.7
Male	121	40	39	24	18	66.9
Age (yr)							2.920	0.417
≤ 61	90	22	33	23	12	75.6
> 61	88	29	30	15	14	67.0
Borrmann type								0.1951
Bor I type	4	0	3	0	1	100
Bor II type	22	6	9	7	0	72.7
Bor III type	140	41	48	27	24	70.7
Bor IV type	12	4	3	4	1	66.7
WHO’s histological types								< 0.0011
Papillary. ade.	2	0	1	1	0	100
Well-diff. ade.	9	3	2	2	2	66.7	17.872	< 0.0012
Moderately-diff. ade.	65	8	28	11	18	87.7
Poorly-diff. ade.	74	27	27	16	4	63.5
Undiff. ade.	3	0	1	2	0	100
Mucinous ade.	19	11	3	3	2	42.1
SRC	6	2	1	3	0	66.7
Lauren’s types							28.523	< 0.001
Intestinal type	74	11	29	14	20	68.4	19.566	< 0.0013
Diffused type	85	29	31	21	4	65.9
Mixed type	19	11	3	3	2	42.1
Lymph node metastasis							12.394	0.006
No	49	23	14	9	3	53.1
Yes	129	28	49	29	23	78.3

¹Fisher’s exact test;

²Well-Moderately-diff. vs Poorly-diff. ade;

³Intestinal type vs Diffused type. ade.: Adenocarcinomas; diff.: Differentiated; SRC: Signet ring cell carcinoma.