Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats

doi:10.3748/wjg.v16.i48.6111

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Dec 28, 2010 (publication date) through Jul 4, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 28, 2010; 16(48): 6111-6118
Published online Dec 28, 2010. doi: 10.3748/wjg.v16.i48.6111

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Figure 3 Changes in the membrane potential of hepatocyte mitochondria. Fluorescence intensity (MFI) of Rh123 was 389.385% ± 18.612% in the normal control (NC) group, but decreased to 268.326% ± 13.526% in the high-fat group (HFD); and in PI3K and Akt blocker groups, MFI had a very similar change (211.326% ± 12.114%, 214.326% ± 13.321%, respectively), indicating a decrease in the mitochondrial membrane potential (Dym) in high-fat, PI3K and Akt blocker groups. ^aP < 0.05 vs NC group.

Citation: Han JW, Zhan XR, Li XY, Xia B, Wang YY, Zhang J, Li BX. Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats. World J Gastroenterol 2010; 16(48): 6111-6118
URL: https://www.wjgnet.com/1007-9327/full/v16/i48/6111.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i48.6111