Role of nitric oxide in hepatic ischemia-reperfusion injury

Table 2 Nitric oxide donors

Model	Drugs	Outcomes	Ref.
Canine liver IRI	FK-409	Promoted hepatic tissue blood flow, decreased serum endothelin-1, cytoprotection	[34]
Isolated hepatocytes	S-nitroso-N-acetylpenicillamine	Drug induced the expression of heat shock protein 70 mRNA and protein resulting in cytoprotection from TNFα	[2]
Murine liver IRI	Sodium nitroprusside	Promotes hepatic tissue blood flow after reperfusion-cytoprotection	[36]
Murine liver IRI	PEG-poly SNO-BSA, a sustained release of NO	Decreased neutrophil accumulation, prevented the excessive production of iNOS	[54]
Murine liver IRI	Macromolecule S-nitrosothiols	Prevented hepatocellular injury	[55]

NO: Nitric oxide; SNO: S-nitrosothiol; iNOS: Inducible nitric oxide synthase; IRI: Ischemia-reperfusion injury; TNF: Tumor necrosis factor.