Prognostic values of chromosome 18q microsatellite alterations in stage II colonic carcinoma

Table 3 Correlation between loss of heterozygosity at chromosome 18q, microsatellite instability and clinicopathologic variables of patients n (%)

Characteristics	Cases	LOH (+)	LOH (-)	P value	MSI-H (%)	MSI-L/MSS (%)	P value
Gender				0.662			0.272
Male	63 (61.8)	27	36		9	54
Female	39 (38.2)	23	16		9	30
Age (yr)				0.435			0.111
≤ 60	58 (56.9)	32	26		11	47
> 60	44 (43.1)	18	26		7	37
Tumor site				0.023			< 0.001
Right colon	46 (45.1)	13	33		15	31
Left colon	56 (54.9)	37	19		3	53
Tumor size (cm)				0.232			0.327
< 5	48 (47.1)	28	20		8	40
≥ 5	54 (52.9)	22	32		10	44
Grade				0.016			0.047
Well/moderately differentiated	78 (76.5)	34	44		15	63
Poorly differentiated	24 (23.5)	16	8		3	21
Histologic features				0.005			0.004
Adenocarcinoma	77 (75.5)	44	33		5	72
Mucinous	25 (24.5)	6	19		13	12
pT stage				0.126			0.272
T3	61 (59.8)	33	28		11	50
T4	41 (40.2)	17	24		7	34
Chemotherapy				0.650			0.782
No	17 (16.7)	10	7		4	13
Yes	85 (83.3)	40	45		14	71

LOH: Loss of heterozygosity; MSI-L: Low frequency microsatellite instability; MSI-H: High frequency of microsatellite instability; MSS: Microsatellite stable.