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World J Gastroenterol. Dec 21, 2010; 16(47): 6026-6034
Published online Dec 21, 2010. doi: 10.3748/wjg.v16.i47.6026
Published online Dec 21, 2010. doi: 10.3748/wjg.v16.i47.6026
Table 3 Correlation between loss of heterozygosity at chromosome 18q, microsatellite instability and clinicopathologic variables of patients n (%)
Characteristics | Cases | LOH (+) | LOH (-) | P value | MSI-H (%) | MSI-L/MSS (%) | P value |
Gender | 0.662 | 0.272 | |||||
Male | 63 (61.8) | 27 | 36 | 9 | 54 | ||
Female | 39 (38.2) | 23 | 16 | 9 | 30 | ||
Age (yr) | 0.435 | 0.111 | |||||
≤ 60 | 58 (56.9) | 32 | 26 | 11 | 47 | ||
> 60 | 44 (43.1) | 18 | 26 | 7 | 37 | ||
Tumor site | 0.023 | < 0.001 | |||||
Right colon | 46 (45.1) | 13 | 33 | 15 | 31 | ||
Left colon | 56 (54.9) | 37 | 19 | 3 | 53 | ||
Tumor size (cm) | 0.232 | 0.327 | |||||
< 5 | 48 (47.1) | 28 | 20 | 8 | 40 | ||
≥ 5 | 54 (52.9) | 22 | 32 | 10 | 44 | ||
Grade | 0.016 | 0.047 | |||||
Well/moderately differentiated | 78 (76.5) | 34 | 44 | 15 | 63 | ||
Poorly differentiated | 24 (23.5) | 16 | 8 | 3 | 21 | ||
Histologic features | 0.005 | 0.004 | |||||
Adenocarcinoma | 77 (75.5) | 44 | 33 | 5 | 72 | ||
Mucinous | 25 (24.5) | 6 | 19 | 13 | 12 | ||
pT stage | 0.126 | 0.272 | |||||
T3 | 61 (59.8) | 33 | 28 | 11 | 50 | ||
T4 | 41 (40.2) | 17 | 24 | 7 | 34 | ||
Chemotherapy | 0.650 | 0.782 | |||||
No | 17 (16.7) | 10 | 7 | 4 | 13 | ||
Yes | 85 (83.3) | 40 | 45 | 14 | 71 |
- Citation: Wang W, Wang GQ, Sun XW, Chen G, Li YF, Zhang LY, Qiu HB, Huang CY, Zhan YQ, Zhou ZW. Prognostic values of chromosome 18q microsatellite alterations in stage II colonic carcinoma. World J Gastroenterol 2010; 16(47): 6026-6034
- URL: https://www.wjgnet.com/1007-9327/full/v16/i47/6026.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i47.6026