Immune phenotype in children with therapy-na&iuml;ve remitted and relapsed Crohn&rsquo;s disease

doi:10.3748/wjg.v16.i47.6001

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2010; 16(47): 6001-6009
Published online Dec 21, 2010. doi: 10.3748/wjg.v16.i47.6001

Table 2 Prevalence and ratios of cellular members of adaptive immunity

Cell prevalence in parent population	Control	Therapy-naïve (before conventional therapy)	First remission (with conventional therapy)	Relapse (before IFX therapy)	IFX therapy (before 2nd infusion)	IFX therapy (before 3rd infusion)
CD4⁺ in PBMC	35.16 (24.81-47.79)	36.52 (18.61-44.06)	37.42 (22.27-44.26)	39.12 (24.15-51.18)	39.77 (27.71-50.30)	35.65 (24.31-48.81)
Activated in CD4⁺	5.92 (2.39-6.51)	10.61 (3.93-19.04)^a	5.03 (3.37-7.93)^g	7.84 (5.30-11.67)^a	7.24 (5.67-12.25)^a	9.98 (5.45-16.19)^b
Naïve in CD4⁺	64.57 (59.86-73.03)	63.36 (41.19-74.86)	61.31 (39.09-73.05)	66.31 (60.44-71.79)	64.47 (53.90-77.87)	58.11 (53.51-64.96)
Effector in CD4⁺	21.91 (13.94-33.96)	31.29 (22.80-55.78)^a	33.97 (28.54-39.44)^a	29.47 (26.54-36.19)^a	35.23 (27.74-40.36)^a	37.62 (35.74-45.24)^bⁱ
Naïve/effector ratio	2.73 (1.60-4.97)	1.57 (1.02-2.54)^a	1.43 (1.14-2.21)^a	2.34 (1.66-2.68)	1.79 (1.47-2.36)	1.52 (1.19-1.74)^a^e
Th1 in CD4⁺	16.19 (9.91-25.26)	6.49 (4.50-7.67)^d	12.89 (5.12-19.03)^c	10.9 (4.03-14.38)^a	12.73 (8.12-15.81)	18.87 (12.51-38.11)^e
Th2 in CD4⁺	4.59 (2.78-5.51)	4.7 (1.98-6.03)	5.06 (1.42-8.48)	3.97 (2.27-7.19)	4.61 (2.55-5.65)	4.46 (2.11-8.16)
Th1/Th2 ratio	3.98 (3.06-5.12)	1.60 (0.50-2.11)^d	1.95 (0.43-3.62)^b	2.68 (0.85-5.07)	2.68 (1.42-6.14)	3.25 (1.37-4.80)^e
Treg in CD4⁺	1.25 (1.10-2.37)	1.36 (1.09-2.48)	1.41 (1.07-3.50)	1.31 (1.16-2.63)	1.33 (1.07-2.99)	1.96 (1.47-3.77)^b^e

^aP < 0.05,

^bP < 0.01,

^dP < 0.01 vs control;

^cP < 0.05,

^gP < 0.01 vs therapy-naïve;

^eP < 0.05,

ⁱP < 0.01 vs relapse. Data are expressed as median (interquartile range). IFX: Infliximab; PBMC: Peripheral blood mononuclear cell; Activated (CD25⁺); Naïve (CD45RA⁺); Effector (CD45RO⁺); Th1: T helper 1 committed, CXCR3⁺; Th2: T helper 2 committed, CCR4⁺; Treg: Regulatory T lymphocytes, CD25^hiFoxP3⁺.

Citation: Cseh A, Vasarhelyi B, Molnar K, Szalay B, Svec P, Treszl A, Dezsofi A, Lakatos PL, Arato A, Tulassay T, Veres G. Immune phenotype in children with therapy-naïve remitted and relapsed Crohn’s disease. World J Gastroenterol 2010; 16(47): 6001-6009
URL: https://www.wjgnet.com/1007-9327/full/v16/i47/6001.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i47.6001