Nitric oxide activation of a potassium channel (BKCa) in feline lower esophageal sphincter

Figure 3 Representative traces and quantification of the effect of L-NNA (10^-4 mol/L) on elicited outward K⁺ currents using a ramp protocol from -70 to +70 mV of lower esophageal sphincter circular (n = 8) and sling (n = 8) smooth muscle cells. Addition of L-NNA led to an insignificant 14% decrease in outward potassium currents in the circular smooth muscle cells. In the sling smooth muscle cells, the addition of L-NNA led to an insignificant 7% reduction in current density.